Regulation of intestinal stem cell fate specification
نویسندگان
چکیده
منابع مشابه
Regulation of Stem Cell Proliferation and Cell Fate Specification by Wingless/Wnt Signaling Gradients Enriched at Adult Intestinal Compartment Boundaries
Intestinal stem cell (ISC) self-renewal and proliferation are directed by Wnt/β-catenin signaling in mammals, whereas aberrant Wnt pathway activation in ISCs triggers the development of human colorectal carcinoma. Herein, we have utilized the Drosophila midgut, a powerful model for ISC regulation, to elucidate the mechanisms by which Wingless (Wg)/Wnt regulates intestinal homeostasis and develo...
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ژورنال
عنوان ژورنال: Science China Life Sciences
سال: 2015
ISSN: 1674-7305,1869-1889
DOI: 10.1007/s11427-015-4859-7